Arizona vs. Iowa State prediction, odds, spread: 2025 college basketball picks, Jan. 27 bets by proven model

 The 2024-25 college basketball season continues on Monday and the action for the night will wrap up with a high-profile Big 12 matchup between the Arizona Wildcats and the Iowa State Cyclones. Arizona will host and is 13-6 on the season with a 7-1 record in conference play while No. 3 Iowa State is 17-2 overall and is also 7-1 in the league. Both of these programs were No. 2 seeds in last year's NCAA tournament and were knocked out in the Sweet 16 and now the powers will begin a new era as rivals in the Big 12 after Arizona left the Pac-12 this offseason.

Tipoff from the McKale Memorial Center in Tucson, Ariz., is set for 10:30 p.m. ET. The Wildcats are favored by 2.5 points in the latest Arizona vs. Iowa State odds from SportsLine consensus, and the over/under is 152.5 points. Before entering any Iowa State vs. Arizona picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 13 of the 2024-25 season on a 202-142 betting roll (+2468) on all top-rated college basketball picks dating back to 2023. Anyone following at sportsbooks and on betting apps could have seen huge returns.

The model has set its sights on Arizona vs. Iowa State. You can head to SportsLine to see its picks. Here are several college basketball betting lines and trends for Iowa State vs. Arizona: